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Deductive, Systematic Signal Validation as Method for Efficacy Improvement in Pharmaco- and Chemo-Vigilance

1. Deutscher Kongress für Patientensicherheit bei medikamentöser Therapie, April 19th – 20th, Congresshalle, Saarbrücken, Germany - R. Arno Wess, Joseph Gut and Robert Dannecker

Scientific Essay 2005 1 Pages

Pharmacology

Summary

Signal Validation can lead Vigilance
Just single ADRs relating the known benzene – toxicologic endpoints (leukemia, breast cancer) and these substances are worth to be investigated completely, since they enable risk assessments based on predisposition and epidemiology much earlier. The need of intelligence tools to deal with such heterogeneous data is obvious. The paradoxical situation that often arises is characterized by information overload but knowledge deficiency, and the need for intellectual involvement in information assimilation4. IT tools for intelligence are designed to assess risks in situations when only bits and pieces of knowledge are available but the situation forces to find the trace of future and past events (like it is the case in criminology, counter-terrorism, and military intelligence).

Details

Pages
1
Year
2005
ISBN (eBook)
9783640312337
File size
893 KB
Language
English
Catalog Number
v125407
Grade
Keine
Tags
Bezene toxicity Signal Validation Pharmacovigilance Translational Medicine Read-Across Crossing pathways Benzene toxicity In silico

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Title: Deductive, Systematic Signal Validation as Method for Efficacy Improvement in Pharmaco- and Chemo-Vigilance