Part I - Introduce your topic by clearly identifying the two variables that are of interest to you. Citing previous research, state the hypothesized association between the two variables as well as the direction(s) of that relationship. Briefly trace the historical development of the theory connecting the two variables.
Topic: H1NI virus and Mortality among Black and Hispanic Children with Asthma.
The H1N1 virus is a variable that is of interest and will be discussed as one of the variables in the study. A new research by an anonymous author from the University of California reveals recent research from the United States, which shows that, in the year 1977, H1N1 influenza A virus reappeared after a 20-year absence. Genetic analysis indicated that this strain was missing decades of nucleotide sequence evolution, suggesting an accidental release of a frozen laboratory strain into the general population. The author shows that recently, this strain and its descendants were included in an analysis attempting to date the origin of pandemic influenza virus without accounting for the missing decades of evolution. Here, we investigated the effect of using viral isolates with biologically unrealistic sampling dates on estimates of divergence dates. Not accounting for missing sequence evolution produced biased results and increased the variance of date estimates of the most recent common ancestor of the re-emergent lineages and across the entire phylogeny. Reanalysis of the H1N1 sequences excluding isolates with unrealistic sampling dates indicates that the 1977 re-emergent lineage was circulating for approximately one year before detection, making it difficult to determine the geographic source of reintroduction.
Mortality in Black and Hispanic children with asthma is another variable that will be discussed. An article by Ayi (2006) shows black children are 25 percent more likely to die and 50 percent more likely to be hospitalized for asthma, according to a report in the February issue of the Journal of Allergy and Clinical Immunology. The author also explains that asthma-related death rates have remained about the same for white children as well as hospitalization rates have decreased. However hospitalization and death rates for Black children have increased. The research conducted by Ayi (2006) showed that nationally, an average of 12 white children died from asthma each year, but an average of 46 Black died from the same condition. Previous studies have hypothesized association between H1N1 virus and mortality in African American children with asthma. Article from Center for Disease Control and Prevention shows from April 2009 to September 2009, almost one-third of people hospitalized with complications from 2009 H1N1 influenza were persons with asthma. Asthma-related hospitalization and mortality rates from all causes, not just influenza, are approximately two to three times higher among non-Hispanic blacks compared with non-Hispanic whites.