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How many mutations are required to produce a human cancer cell?

Assessment of theoretical models and their experimental support


Bachelor Thesis, 2011

35 Pages


Excerpt


Contents

Introduction

How many mutations are required to produce a human cancer cell?
Sequence data
Epidemiology
In vitro data
Histopathology

Is genetic instability necessary to acquire sufficient mutations?
The mutator phenotype hypothesis
Arguments which undermine the calculations’ assumptions
Clonal evolution and natural selection
Arguments for the calculations validity
Tissue Biology
Epigenetics
CpG island promoter hypermethylation
Global CpG hypomethylation

Does genetic instability accelerate tumour progression?
Cell clone ecology hypothesis
Mathematical assessment
Lab based test
Clinical data
Sequence Data
Implications for therapy
Conclusion

Bibliography

Excerpt out of 35 pages

Details

Title
How many mutations are required to produce a human cancer cell?
Subtitle
Assessment of theoretical models and their experimental support
College
University of Cambridge
Author
Year
2011
Pages
35
Catalog Number
V168293
ISBN (eBook)
9783640852963
ISBN (Book)
9783640853410
File size
1018 KB
Language
English
Keywords
Cancer;, genetic instability;, Mutation;
Quote paper
Pascal Kaufmann (Author), 2011, How many mutations are required to produce a human cancer cell?, Munich, GRIN Verlag, https://www.grin.com/document/168293

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